ABOUT TRAMADOL (RETARD)

Opioid action is due to the two very low affinity binding in the father or mother compound and better affinity binding from the O-demethylated metabolite M1 to μ-opioid receptors. In animal styles, M1 is nearly six occasions a lot more powerful than tramadol in developing analgesia and two hundred instances extra strong in μ-opioid binding.The si